Iodinated Dopamine D1 and D2 Receptor Imaging Agents for SPECT

TL;DRAbstract

In vivo imaging of the dopaminergic system in the mammalian brain has been the subject of extensive studies in recent years. Not only is this part of the central nervous system (CNS) very important for normal brain function, it is also a possible primary action site for antiparkinsonian agents or neuroleptic drugs for schizophrenia. Addiction to cocaine, which is an acute social and economic problem, is related to the CNS reward system involving dopaminergic function. Binding of cocaine to the dopamine reuptake sites, which leaves more dopamine in the synaptic cleft for binding to the postsynaptic neuron, is the primary mechanism for stimulation. There is a wealth of pharmacological information about the dopamine receptor (Creese and Fraser, 1987; Beaulieu, 1987; Waddington, 1986; Waddington, 1989; Stoof and Kebabian, 1984; Waddington and O’Boyle, 1987; Waddington and O’Boyle, 1989; Sidhu et al., 1991).

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