Activation of mesenteric arteries and veins by preganglionic and postganglionic nerves

TL;DRAbstract

Intracellular recordings were made from inferior mesenteric artery and vein and their primary and secondary branches. The major nerve trunks associated with the inferior mesenteric ganglion were stimulated with single shocks and repetitively. Excitatory junction potentials (EJPs) were recorded in arterial cells but not in veins. Stimulation of the postganglionic lumbar colonic nerves elicited the largest EJPs; stimulation of preganglionic lumbar splanchnic nerves or the interganglionic intermesenteric nerves elicited EJPs that were 40 and 44%, respectively, of the amplitude of the EJPs elicited with lumbar colonic nerve stimulation. In response to repetitive stimulation, the membranes of both artery and vein cells depolarized by an amount dependent on the frequency and duration of stimulation. At a given frequency of stimulation, the vein cells depolarized more rapidly and constricted sooner than the arterial cells. The depolarizations and the associated constrictions were attenuated b

Chat with Paper

AI Agents for this Paper