THE ANEMIA-PRODUCING PROPERTIES OF α-AMINO-ε-HYDROXYCAPROIC ACID

TL;DRAbstract

In the course of a new synthesis of lysine, cu-amino+hydroxycaproic acid was isolated as an intermediary compound.lIt was shown that it could not replace lysine in the diet of rats and that it was probably toxic.Upon publication of these original findings,2 Dr.Richard J. Block drew our attention to the probable identity of this compound with the anemiaproducing factor known to exist in deaminized casein.This was investigated.In a first experiment, twenty-one male rats averaging 90 gm. in body weight were put on the following diet: zein 17.4, nL-tryptophan 0.4, soy bean oil 4.0, salts 4.0, cerelose 72, and Cellu flour 2.0 gm. per cent.100 gm. of ration contained thiamine HCl 0.4, riboflavin 0.5, pyridoxine HCl 0.5, calcium pantothenate 3.0, nicotinic acid 3.0, 2-methyl-1,4-naphthoquinone 0.1, inositol 10, and choline chloride 150 mg.After 10 days, the rats were divided into three groups.Group I received 1.5 per cent aamino-e-hydroxycaproic acid and Group II received 1.5 per cent DLlysin

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