Key Role for Matrix Metalloproteinases -19 and -28 in Maintenance of Intestinal Homeostasis

TL;DRAbstract

The present study investigates the role of two matrix metalloproteinases, MMP-19 and MMP-28, in intestinal homeostasis and inflammation by means of a mouse model for inflammatory bowel disease (IBD). MMP-19 and -28 are abundantly expressed in epithelial tissues. However, their functions in this compartment and their functional overlap have not been elucidated so far. MMP-19 contributes to IGF-signaling, cell proliferation, and migration and is able to cleave several soluble proteins and components of extracellular matrix. MMP-28 was shown to be important in wound healing. Comparison of wildtype and MMP-19-deficient mice revealed an increased susceptibility to acute and chronic DSS-induced colitis accompanied by impaired healing process compared to the wildtype animals. Survival rates during acute and chronic colitis were significantly reduced. In contrast, the MMP-28-deficient mice show only moderate signs of disease and behaved similarly to the DSS-treated wildtype group. Strikingly,

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