SU‐E‐T‐518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy

doi:https://doi.org/10.1118/1.4924880

SU‐E‐T‐518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy

Yu-Ting Lin,Kathryn D. Held,Stephen J. McMahon,Harald Paganetti,Jan Schuemann-2015-06-01-Medical Physics

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TL;DRAbstract

Purpose The aim of this work is to investigate the radiosensitization effect of gold nanoparticles (GNP) in carbon ion irradiation. Nano‐scale dosimetric characteristics of GNP interaction with carbon ions as well as the secondary particles generated as a carbon beam traverses the water phantom were studied. Methods Monte Carlo simulations were carried out using TOPAS (Tool for Particle Simulation). First, a water phantom was irradiated by the carbon ion beam and the particle shower spectrum at several depths was recorded in phase spaces. We analyzed the number and energy spectrum of each particle type. Then, the phase spaces obtained from Step 1 were modified to nanometer scale to irradiate a single 50 nm GNP. The secondary electrons that escaped from the GNPs following interactions with each particle type were recorded as phase spaces. The number and energy spectrum of the secondary electrons were studied. The same simulations were repeated replacing the GNPs with water nanoparticles

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Purpose The aim of this work is to investigate the radiosensitization effect of gold nanoparticles (GNP) in carbon ion irradiation. Nano‐scale dosimetric characteristics of GNP interaction with carbon ions as well as the secondary particles generated as a carbon beam traverses the water phantom were studied. Methods Monte Carlo simulations were carried out using TOPAS (Tool for Particle Simulation). First, a water phantom was irradiated by the carbon ion beam and the particle shower spectrum at several depths was recorded in phase spaces. We analyzed the number and energy spectrum of each particle type. Then, the phase spaces obtained from Step 1 were modified to nanometer scale to irradiate a single 50 nm GNP. The secondary electrons that escaped from the GNPs following interactions with each particle type were recorded as phase spaces. The number and energy spectrum of the secondary electrons were studied. The same simulations were repeated replacing the GNPs with water nanoparticles

Keywords

Secondary electronsCarbon fibersMaterials scienceIrradiationIonParticle (ecology)Colloidal goldElectron

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