Pharmacological Probes for AMPA Receptors
TL;DRAbstract
Alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isooxazolepropionic acid (AMPA) receptors are a family of glutamate‐gated ion channels that mediate the majority of fast, excitatory synaptic transmission in the mammalian central nervous system. In addition, changes in the efficacy of AMPA receptor mediated synaptic responses underlie many forms of normal plasticity (e.g. long‐term potentiation and memory). Moreover, AMPA receptors have been implicated in several neuropathologies (e.g. schizophrenia and Alzheimer's disease). Changes in the expression pattern of AMPA receptors may provide a molecular basis for both normal and maladaptive forms of plasticity. Data describing the development and use of novel pharmacological tools for studying the activity of AMPA receptors will be presented.
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Alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isooxazolepropionic acid (AMPA) receptors are a family of glutamate‐gated ion channels that mediate the majority of fast, excitatory synaptic transmission in the mammalian central nervous system. In addition, changes in the efficacy of AMPA receptor mediated synaptic responses underlie many forms of normal plasticity (e.g. long‐term potentiation and memory). Moreover, AMPA receptors have been implicated in several neuropathologies (e.g. schizophrenia and Alzheimer's disease). Changes in the expression pattern of AMPA receptors may provide a molecular basis for both normal and maladaptive forms of plasticity. Data describing the development and use of novel pharmacological tools for studying the activity of AMPA receptors will be presented.
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