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Article10.1161/circ.120.suppl_18.s1060-d

Abstract 5147: GLP-1 Improves Insulin-Stimulated Nitric Oxide-Dependent Vasodilator Responsiveness in Patients With Metabolic Syndrome

Manfredi Tesauro,Francesca Schinzari,Valentina Rovella,Nadia Mores,Dario Pitocco,Giovanni Ghirlanda+2 more-2009-11-03-Circulation
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TL;DRAbstract

Our previous work has shown that patients with metabolic syndrome (MetS) have impaired insulin-stimulated vasodilation, which may be involved in the development of hypertension and contribute to insulin resistance by affecting the glucose uptake. Glucagon-like peptide-1 (GLP-1), an amino acid gut hormone that stimulates both insulin secretion and sensitivity, is also provided of cardioprotective and vasoactive properties. We therefore examined the effects of exogenous GLP-1 on insulin-stimulated, nitric oxide (NO)-dependent vasodilation in patients with obesity-related MetS by use of the forearm perfusion technique. Forearm blood flow (FBF) responses to intra-arterial infusion of graded doses of acetylcholine (ACh; stimulus for endothelial release of NO) and sodium nitroprusside (SNP; exogenous NO donor) were assessed in 10 patients with MetS during coinfusion of either saline or regular insulin (0.2 mU/Kg/min). Thereafter, patients underwent to intra-arterial infusion of GLP-1 (30 ng/

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Our previous work has shown that patients with metabolic syndrome (MetS) have impaired insulin-stimulated vasodilation, which may be involved in the development of hypertension and contribute to insulin resistance by affecting the glucose uptake. Glucagon-like peptide-1 (GLP-1), an amino acid gut hormone that stimulates both insulin secretion and sensitivity, is also provided of cardioprotective and vasoactive properties. We therefore examined the effects of exogenous GLP-1 on insulin-stimulated, nitric oxide (NO)-dependent vasodilation in patients with obesity-related MetS by use of the forearm perfusion technique. Forearm blood flow (FBF) responses to intra-arterial infusion of graded doses of acetylcholine (ACh; stimulus for endothelial release of NO) and sodium nitroprusside (SNP; exogenous NO donor) were assessed in 10 patients with MetS during coinfusion of either saline or regular insulin (0.2 mU/Kg/min). Thereafter, patients underwent to intra-arterial infusion of GLP-1 (30 ng/

Keywords

MedicineNitric oxideMetabolic syndromeVasodilationInsulinInternal medicineEndocrinologyPharmacology

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