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Atomic force microscopy investigation of virus aggregation and assembly at chemical templates formed by scanned probe nanolithography

Chin Li Cheung,Sungwook Chung,James J. De Yoreo,Anju Chatterji,Tianwei Lin,Jack E. Johnson-2005-01-01-Insecta mundi
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TL;DRAbstract

Aggregation and assembly of macromolecules are important processes in a number of scientific fields including structural biology, medicine, and materials science. For example, growth of well-ordered two-dimensional (2-D) arrays and bulk crystals remains the rate-limiting step in macromolecular structure determination. Uncontrolled aggregation of proteins is the source of a number of devastating pathologies such as Creutzfeldt-Jakob syndrome. Moreover, the demonstrated ability of engineered viruses and proteins to act as templates for growth of inorganic nanostructures is driving a need for methods to deterministically pattern their assembly at surfaces in order to fabricate hierarchical materials and devices.

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Aggregation and assembly of macromolecules are important processes in a number of scientific fields including structural biology, medicine, and materials science. For example, growth of well-ordered two-dimensional (2-D) arrays and bulk crystals remains the rate-limiting step in macromolecular structure determination. Uncontrolled aggregation of proteins is the source of a number of devastating pathologies such as Creutzfeldt-Jakob syndrome. Moreover, the demonstrated ability of engineered viruses and proteins to act as templates for growth of inorganic nanostructures is driving a need for methods to deterministically pattern their assembly at surfaces in order to fabricate hierarchical materials and devices.

Keywords

NanolithographyDip-pen nanolithographyNanotechnologyAtomic force microscopyTemplateMaterials scienceMicroscopyLithography

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