Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel
Edward Yepes,Rubén E. Varela-M,Julio López‐Abán,José Rojas-Caraballo,Antonio Muro,Faustino Mollinedo-2015-07-20-PLoS neglected tropical diseases
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TL;DRAbstract
Taken together, these data suggest that the combined treatment of PZQ and edelfosine promotes a high decrease in granuloma formation, as well as in the cellular immune response that underlies granuloma development, with changes in the cytokine patterns, and may provide a promising and effective strategy for a prophylactic treatment of schistosomiasis.
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Taken together, these data suggest that the combined treatment of PZQ and edelfosine promotes a high decrease in granuloma formation, as well as in the cellular immune response that underlies granuloma development, with changes in the cytokine patterns, and may provide a promising and effective strategy for a prophylactic treatment of schistosomiasis.
Keywords
PraziquantelSchistosomiasisSchistosoma mansoniSchistosomaGranulomaImmunologyBiologyInflammation
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