Bronchial microdialysis monitoring inflammatory response in open abdominal aortic aneurysm repair

TL;DRAbstract

This thesis describes the stepwise development of a new method for monitoring the dynamic composition of the epithelial lining fluid in bronchi in large animals and humans. The starting point was the belief that existing methods had significant limitations. Existing methods were invasive and their use created lung injury or failed to measure substances of interest. The idea was to find a method for continuous measurement that did not harm patients. The method was to be evaluated monitoring lung involvement in organ crosstalk after experimental intestinal ischemia-reperfusion injury and during aortic surgery.The first paper evaluated microdialysis in the bronchi and blood in an experimental setting with controlled blood-concentration of one small substance (lactate) and one larger substance (fluorescein-isothiocyanate-dextran 4000Da). We concluded that bronchial microdialysis could measure concentration of substances within the bronchial epithelial lining fluid. The use of the concentra

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