Activities of Enzymes of the Citric Acid Cycleand Electron Transport Chain in the Skeletal Muscleof Normal and Dystrophic Mice (Strain 129)

TL;DRAbstract

The enzymatic activities of the citric acid cycle and the electron transport chain have been determined in mitochondria isolated from the hind leg muscle of normal and dystrophic mice (strain 129). No significant difference between enzymatic activity of normal and dystrophic muscle was found with any of the enzymes studied. There is evidence of an increased mitochondrial content in dystrophic muscle as calculated by succinate dehydrogenase activity in whole muscle homogenate relative to the activity in isolated mitochondria. Despite the increased mitochondrial content there is a lower yield of mitochondria from dystrophic muscle that is believed due to increased fragility of the mitochondria in this condition.

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