Telomere DNA Content: Correlation with Survival in Advanced Prostate Cancer.

TL;DRAbstract

The goal of this project is to test the hypothesis that the content of telomere DNA in clinically localized prostate cancers has independent prognostic significance. If so, then telomere DNA content may discriminate high-risk patients that are most likely to benefit from therapy from low risk patients who can be spared unnecessary side effects and expense by management with "watchful waiting". This hypothesis is being tested by comparing telomere DNA content in archival prostate cancer tissue from surviving and non-surviving men who received prostatectomies for clinically localized prostate cancer between 1986 and 1992. During the past year, 110 men have been entered into the study group, including 24 men who died from prostate cancer, 4 surviving men that had received orchiectomy for serious recurrent disease (poor outcomes) and 82 men who have remained disease-free (good outcomes). Archival tissue blocks have been obtained for 65 members of the study group and examined histologically

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