Effect of rifampicin and tetracycline alone and in combination against Brucella suis.

TL;DRAbstract

In vivo and in vitro efficacy of rifampicin and tetracycline hydrochloride, used alone and in combination, was tested against one strain of Brucella suis. The minimal inhibitory concentrations of rifampicin and tetracycline hydrochloride against this strain were 2 and 0.2 microgram/ml, respectively. In vitro efficacy was evaluated by inhibition of bacterial growth in liquid medium. Rifampicin killed 99.9% of the Brucella after 18 h of incubation of concentrations of 2 and 4 microgram/ml. Tetracycline hydrochloride was bacteriostatic at concentrations of 0.2 and 0.4 microgram/ml. Combinations of rifampicin and tetracycline hydrochloride had the same bactericidal efficacy as rifampicin alone when bactericidal concentrations of rifampicin (greater than 2 microgram/ml) were used. In contrast, a highly additive effect was observed with combinations containing non-bactericidal concentrations of rifampicin (less than 2 microgram/ml). In vivo efficacy was tested in experimentally infected mice

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