KORELASI TGF-β1 PRODUK MONOSIT DARAH TEPIDENGAN KEBOCORAN VASKULER PADA DEMAMBERDARAH DENGUE(Correlation between Monocyte Transforming Growth Factor – Beta 1,and Vascular Leakage in Dengue Hemorrhagic Fever)

TL;DRAbstract

ABSTRACT Background. The generally accepted view that blood monocytes are the principal target of virus infection suggests that virus-infected monocytes may produce a vasoactive factor which might affect endothelial cell function, possibly contributing to vascular leakage. Transforming growth factor beta 1 (TGF-β1) is one of cytokines that plays a variety of roles in pathogenesis of dengue hemorrhagic fever (DHF). Aims. To determine the correlation among TGF-β1 to PEI,total protein, albumin and hematocrit as vascular leakage markers on DHF. Methods. This was an observational study with cross sectional design. Subjects were DHF patients that hospitalized in Dr. Kariadi Hospital during July, 2005 – July 2006,3-14 years old. TGF-s1 product of monocyte, PEI, total protein and albumin levels, and hematocrit were measured on day 0 and 2. The correlation between TGF-β1 levels and PEI, total protein and albumin levels, and hematocrit on day 0 and 2 were analyzed Results. Subject

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