MO‐FG‐BRA‐08: A Preliminary Study of Gold Nanoparticles Enhanced Diffuse Optical Tomography

doi:https://doi.org/10.1118/1.4925412

MO‐FG‐BRA‐08: A Preliminary Study of Gold Nanoparticles Enhanced Diffuse Optical Tomography

Keying Xu,N. Dogan,Yidong Yang-2015-06-01-Medical Physics

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TL;DRAbstract

Purpose: To develop an imaging method by using gold nanoparticles (GNP) to enhance diffuse optical tomography (DOT) for better tumor detection. Methods: Experiments were performed on a tissue‐simulating cylindrical optical phantom (30mm diameter, 60mm length). The GNP used are gold nanorods (10nm diameter, 44nm length) with peak light absorption at 840nm. 0.085ml GNP colloid of 96nM concentration was loaded into a 6mm diameter cylindrical hole in the phantom. An 856nm laser beam (14mW) was used as light source to irradiate the phantom at multiple locations through rotating and elevating the phantom. A CCD camera captured the light transmission through the phantom for each irradiation with total 40 projections (8 rotation angles in 45degree steps and 5 elevations with 3mm apart). Cone beam CT of the phantom was used to generate the three‐dimensional mesh for DOT reconstruction and to identify the true location of the GNP volume. A forward simulation was performed with known phantom opti

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Purpose: To develop an imaging method by using gold nanoparticles (GNP) to enhance diffuse optical tomography (DOT) for better tumor detection. Methods: Experiments were performed on a tissue‐simulating cylindrical optical phantom (30mm diameter, 60mm length). The GNP used are gold nanorods (10nm diameter, 44nm length) with peak light absorption at 840nm. 0.085ml GNP colloid of 96nM concentration was loaded into a 6mm diameter cylindrical hole in the phantom. An 856nm laser beam (14mW) was used as light source to irradiate the phantom at multiple locations through rotating and elevating the phantom. A CCD camera captured the light transmission through the phantom for each irradiation with total 40 projections (8 rotation angles in 45degree steps and 5 elevations with 3mm apart). Cone beam CT of the phantom was used to generate the three‐dimensional mesh for DOT reconstruction and to identify the true location of the GNP volume. A forward simulation was performed with known phantom opti

Keywords

Imaging phantomMaterials scienceDiffuse optical imagingOpticsAttenuation coefficientTomographyIterative reconstructionAbsorption (acoustics)

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