Interferência de nanopartículas magnéticas administradas na medula espinal na resposta comportamental a um estímulo mecânico

TL;DRAbstract

Nanoparticles are structures with nanometer dimensions that are emerging to various applications, including that one involved in biological area.According to their synthesis and growth techniques these particles can have magnetic properties with greater or lesser magnitude.The objective of this study was to evaluate whether the magnetic nanoparticles administration in the subarachnoid space of the spinal cord induces changes in the mechanical nociceptive threshold in rats hind-paw.The carbon nanoparticles (nanotubes or nanofibers) were characterized by Raman spectrum and their magnetic characterized by the ferromagnetism behavior was evaluated by the hysteresis curve.The nanoparticles were intrathecally administered in Wistar rats lightly anesthetized with Isoflorano.The behavioral response to mechanical stimulation was assessed by an electronic analgesimeter (electronic Von Frey) that measures the withdrawal mechanical threshold (mechanical nociception).The nanoparticles were classifi

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