Ischemia/Reperfusion Injury

TL;DRAbstract

Survival of traumatic abdominal injuries is essentially a 20th century development. Historically, abdominal wounds were left untreated because of a lack of anesthesia, and repairs were performed only in cases of evisceration. Even after the discovery of ether anesthesia in the mid-19th century, surgery remained controversial because of the documented poor survival. Marian Sims, the American military surgeon, was a proponent of the interventionists, those who advocated laparotomy in an attempt to treat abdominal injuries, but an equally vocal group opposed this strategy. Statistically, most abdominal injuries were fatal in World War I, with the greatest loss among soldiers who developed acute pneumonias. The initial cause of the mortality was thought to be a toxic factor; however, the beneficial effects of whole blood in shock were noted. Of interest is that a woman surgeon, Princess Gedroitz of Russia, observed that prompt treatment greatly reduced mortality during the Russo-Japanese W

Chat with Paper

AI Agents for this Paper