Fungal allergens and allergen nomenclature.

TL;DRAbstract

Inhalation allergy to airborne particles derived from fungi is among the most important allergies. Safety, efficacy and reproducibility of specific allergy management are dependent on detailed knowledge of fungal allergen molecules. Historically, the first allergen molecules to be characterized using biochemical and immunochemical methods were of unknown biological function and a common allergen nomenclature soon became a necessity. The W.H.O. / I.U.I.S. Allergen Nomenclature Sub-committee has now for 20 years maintained the official 'list of allergens', which has become a recognized reference for allergen names. The list is available to the public at the website of the committee, http://www.allergen.org. Research into fungal allergens has recently expanded and the list currently holds 87 fungal allergens. Important fungal allergens include enzymes (enolase, proteases, etc.), ribosomal proteins, and heat shock proteins, derived from species such as Cladosporium and Alternaria spp. (out

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