TL;DRAbstract
Pharmacokinetics is the study of how substances such as drugs and other xenobiotic compounds are transported within living organisms, particularly human beings and animals used as research models. A pharmacokinetic model for a particular drug provides the ability to simulate introduction of the drug into the body (through injection into soft tissue, intravenous administration, absorption from the gut), transport via the circulatory system and delivery to various tissues, excretion (e.g., by the kidney), and perhaps transformation via chemical reactions. Pharmacokinetic models can be useful in predicting and understanding the timescales and concentrations at which drugs appear and disappear from various regions of the body, for setting dosing guidelines for pharmaceuticals and exposure guidelines for toxic compounds, and as a basic research tool for guiding experimental design and analyzing data, as we will see in the examples in this chapter.
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Pharmacokinetics is the study of how substances such as drugs and other xenobiotic compounds are transported within living organisms, particularly human beings and animals used as research models. A pharmacokinetic model for a particular drug provides the ability to simulate introduction of the drug into the body (through injection into soft tissue, intravenous administration, absorption from the gut), transport via the circulatory system and delivery to various tissues, excretion (e.g., by the kidney), and perhaps transformation via chemical reactions. Pharmacokinetic models can be useful in predicting and understanding the timescales and concentrations at which drugs appear and disappear from various regions of the body, for setting dosing guidelines for pharmaceuticals and exposure guidelines for toxic compounds, and as a basic research tool for guiding experimental design and analyzing data, as we will see in the examples in this chapter.
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