Einfluss des GDNF-Rezeptors RET auf die akute MPTP-Toxizität in der Maus

TL;DRAbstract

Idiopathic Parkinson's disease (PD) is a common age-related disease, associated with the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of these neurons leads to the typical symptoms of akinesia, tremor, rigidity and postural instability. Current therapies are limited to treat the symptoms. Halting the degeneration of neurons, or promote their regeneration has so far proved unsuccessful. The activation of the RET (rearranged during transfection)-receptor by the neurotrophin glial cell line-derived neurotrophic factor (GDNF) was identified in preclinical studies as an important factor for survival of dopaminergic neurons. Clinical trials with GDNF led to contradictory results. To investigate the relevance of GDNF receptor RET for neuroprotection in more detail, experimental animal studies in a model of PD were performed. For this purpose, the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was used, which reproduces best the ne

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