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Article10.1161/circ.120.suppl_18.s1049-b

Abstract 5099: Extent and Severity of Coronary Stenosis at Autopsy Varies by Sex in Fatal Cases of Coronary Heart Disease

Nathaniel R. Smilowitz,Judith S. Hochman,Barbara A. Sampson,Sandeep S. Mangalmurti,Jonathan S. Siegfried,Harmony R. Reynolds-2009-11-03-Circulation
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TL;DRAbstract

Background: Recently, the decline in mortality from coronary heart disease (CHD) has slowed in younger age groups, particularly young women. Young women with acute coronary syndromes (ACS) less often have obstructive CHD at angiography. This could reflect pre-hospital death of women with the most severe disease. Hypothesis: There is a sex difference in extent and severity of coronary stenosis on post-mortem evaluation of people who died of CHD. Methods: Reports of NYC medical examiner autopsies conducted on women 21–54 from1/1/06 –12/31/07 were reviewed if CHD was a cause of death (COD) and cocaine toxicology was negative. Women with CHD as immediate COD were matched by age and race to males with CHD as immediate COD. We analyzed severity of coronary stenosis based on the standard definition of “significant” CHD: ≥75% cross sectional area [CSA] stenosis in a major epicardial vessel, corresponding to 50% angiographic diameter stenosis, or ≥50% CSA stenosis in the left main. We assigned

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Background: Recently, the decline in mortality from coronary heart disease (CHD) has slowed in younger age groups, particularly young women. Young women with acute coronary syndromes (ACS) less often have obstructive CHD at angiography. This could reflect pre-hospital death of women with the most severe disease. Hypothesis: There is a sex difference in extent and severity of coronary stenosis on post-mortem evaluation of people who died of CHD. Methods: Reports of NYC medical examiner autopsies conducted on women 21–54 from1/1/06 –12/31/07 were reviewed if CHD was a cause of death (COD) and cocaine toxicology was negative. Women with CHD as immediate COD were matched by age and race to males with CHD as immediate COD. We analyzed severity of coronary stenosis based on the standard definition of “significant” CHD: ≥75% cross sectional area [CSA] stenosis in a major epicardial vessel, corresponding to 50% angiographic diameter stenosis, or ≥50% CSA stenosis in the left main. We assigned

Keywords

MedicineCardiologyAutopsyInternal medicineStenosisCoronary heart diseaseDiseaseCoronary disease

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