Synthesis and reinvestigation of tetrazocines

TL;DRAbstract

This thesis is concerned with the study of tetrazocines. These rare, eight-membered ring systems containing four nitrogen atoms are in the infancy of their development. Little is known of their potential application, properties and generation. It was endeavoured to learn more about this compound class by examining what has been presented in the literature (chapter 1), generating novel tetrazocines (chapter 3 and 4) and finally substantiating existing syntheses, which were viewed as unlikely or doubtful by this research group (chapter 2).
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\nPrevious work from this research group involving the photolytic ring expansion of hexahydropyrrolotriazoles led to a novel 1,2,3,5-tetrazocine system. Hexahydropyrrolotriazoles are cycloaddition products from the reaction of a 1,3- dipole with various activated dipolarophiles. This thesis was concerned with accelerating this reaction, manipulating functionality post cycloaddition and optimising the photochemical ring opening process leadin

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