IL‐5, IL‐8 and tgf‐beta expressions in chronic rhinosinusitis patients with nasal polyps and their correlation to tissue's cellularity and disease relapsing

TL;DRAbstract

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) presents a Th2 profile predominance, with a remarkable eosinophil infiltration and IL-5 secretion. The influence of molecular markers on both histology and recurrence is still misunderstood. To evaluate the gene expression of IL-5, IL-8 and TGF-beta in patients with nasal polyps and control patients, as well as its correlation to tissue cellularity and diseases relapsing. The mRNA expression of the IL-5, IL-8 and TGF-beta protein was analyzed using qRT-PCR in 32 nasal polyps and 7 control samples comparing it with medium turbinate control samples (obtained from patients undergoing aesthetic rhinoplasty). The numbers of eosinophils and neutrophils were counted in samples obtained during surgical procedure, and stained with hematoxylin eosin in an optical microscope. The patients were followed up to three years after surgery, and considered with relapsing disease if there was polyp in the medium meatus through nasal endoscopy. IL-5 and IL

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