RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response
Roelien A. M. Meijering,Marit Wiersma,Denise M.S. van Marion,Deli Zhang,Femke Hoogstra‐Berends,Anne‐Jan Dijkhuis+5 more-2015-07-20-PLoS ONE
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TL;DRAbstract
These results reveal that active RhoA negatively regulates the HSR via attenuation of the HSF1-HSE binding and thus may play a role in sensitizing cells to proteotoxic stimuli.
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These results reveal that active RhoA negatively regulates the HSR via attenuation of the HSF1-HSE binding and thus may play a role in sensitizing cells to proteotoxic stimuli.
Keywords
HSF1RHOAHeat shockCell biologyChemistryCancer researchMedicineBiology
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