In Vitro and In Vivo pro-apoptotic and chemosensitizing effects of alpha-tomatine on human prostate adenocarcinoma/ Lee Sui Ting

TL;DRAbstract

Alpha (α)-tomatine is a major saponin found in tomatoes (Lycopersicon esculentum). The present study investigates the molecular mechanisms by which α-tomatine exerts its anti-cancer effect on human prostatic adenocarcinoma cells. Treatment of human androgen-dependent LNCaP and androgen-independent PC-3 prostate cancer cells with α-tomatine resulted in a concentration-dependent inhibition of cell growth with a halfmaximal efficient concentration (EC50) value of 2.65 ± 0.1 μM and 1.67 ± 0.3 μM, respectively. PC-3 cells appear to be more sensitive to α-tomatine-induced growth inhibition compared to LNCaP cells. Importantly, α-tomatine treatment is also less cytotoxic to non-tumorigenic human liver WRL-68 and human prostatic epithelial RWPE-1 cells. Due to the higher sensitivity of PC-3 cells to α-tomatine and significant morbidity of metastatic androgen-independent prostate cancer, it is of interest to study in greater detail the mechanisms of action of α-tomatine in PC-3 cells. Results f

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