Clinical, X-Ray, and Serologic Changes with Histoplasma Infection

TL;DRAbstract

ALTH 0 UGH considerable information about histoplasmosis has been accumu- lated since this fungus infection was first de- scribed in 1906, much still needs to be learned about the frequency and severity of the dis- ease accompanying primary infection.Follow- ing the classic work of Smith and his colleagues on Coccidioides infection in personnel of the U. S. Army (1), it was decided that such per- sonnel, with their available medical care and complete records, would be an ideal group for a study of histoplasmosis.Consequently, in 1953 a study was initiated at Fort Leavenworth, Kans., by the U. S. Army Hospital on the post and the Public Health Service.Children of Army personnel participated.The study was undertaken to determine the spectrum of illness accompanying Histoplasma infection.This was accomplished by observation of the clinical, X-ray, and serologic changes which accompanied conversion of the skin test from negative to positive.Its basic plan was to find a large number of chil

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