Hypoxia-associated Component of RR-interval Fluctuations in Patients with Obstructive Sleep Apnea Syndrome
TL;DRAbstract
An RR-interval fluctuation has been used as an important clinical tool for identifying a patient at risk in cardiovascular disease. However, the role of hypoxia on RR-interval fluctuations has not been determined. Methods and Results. We performed ambulatory ECGs monitoring and measured overnight arterial oxygen saturation (SpO<sub>2</sub>) in 26 patients with obstructive sleep apnea syndrome in whom sever hypoxia occurred during sleep. By means of maximal entropy method, time series of ECG-RR intervals were transformed into frequencies. The minimal SpO<sub>2</sub> during sleep were compared with spectrum powers of the following frequency ranges; 1) 0.0001 - 0.05 Hz, 2) 0.05 - 0.1 Hz, 3) 0.1 - 0.15 Hz, 4) 0.15 - 0.2 Hz, 5) 0.2 - 0.25 Hz, 6) 0.25 - 0.3 Hz, and 7) 0.3 - 0.5 Hz. Among the seven analyzed frequencies, the increase in the 0.05 - 0.1 Hz power of RR-interval fluctuations was linearly correlated with the minimal SpO<sub>2</sub> during sleep (r=.80, p<.001). Conclusion. This stu
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An RR-interval fluctuation has been used as an important clinical tool for identifying a patient at risk in cardiovascular disease. However, the role of hypoxia on RR-interval fluctuations has not been determined. Methods and Results. We performed ambulatory ECGs monitoring and measured overnight arterial oxygen saturation (SpO<sub>2</sub>) in 26 patients with obstructive sleep apnea syndrome in whom sever hypoxia occurred during sleep. By means of maximal entropy method, time series of ECG-RR intervals were transformed into frequencies. The minimal SpO<sub>2</sub> during sleep were compared with spectrum powers of the following frequency ranges; 1) 0.0001 - 0.05 Hz, 2) 0.05 - 0.1 Hz, 3) 0.1 - 0.15 Hz, 4) 0.15 - 0.2 Hz, 5) 0.2 - 0.25 Hz, 6) 0.25 - 0.3 Hz, and 7) 0.3 - 0.5 Hz. Among the seven analyzed frequencies, the increase in the 0.05 - 0.1 Hz power of RR-interval fluctuations was linearly correlated with the minimal SpO<sub>2</sub> during sleep (r=.80, p<.001). Conclusion. This stu
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