Notions about human stem cells. [Stem cell proliferation]

TL;DRAbstract

Precise characterization of the structure of hemopoiesis in man and its quantitation is required for an understanding of hemopoietic regulation and its response to toxic agents, during and after chemotherapy and radiotherapy, in the course of various diseases, and in individuals exposed to agents known to be or which may be toxic to the bone marrow. Knowledge of stem cell kinetics derives almost exclusively from studies on the mouse. The degree to which this can be applied to man is not known. Mouse and human studies indicate that there is a pluripotent hemopoietic stem cell (PHSC) pool in which less than 20 percent of the cells are in DNA synthesis. The PHSC pool feeds into the committed stem cell (CSC) pools (erythrocytic, granulocytic-monocytic and megakaryocytic lines). The CSC has about 30 to 40 percent of its cells in DNA synthesis under normal steady state conditions. Data on mouse and human stem cell proliferation are summarized.(CH)

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