Adhesion force, neutrophil membrane stiffness and systemic inflammation biomarkers in patients with chronic obstructive pulmonary disease and pulmonary hypertension

TL;DRAbstract

The aim of this study was to investigate blood neutrophil functional properties and the relationships to systemic inflammation in order to better understand a role of systemic inflammation for PH occurrence in COPD patients. Methods . This was a local open comparative study involving 30 patients with COPD (15 patients with PH and 15 patients without PH). The blood neutrophil functional properties (cell membrane stiffness and adhesion force) were measured using the atomic force microscopy. The power spectroscopy was used to quantitatively assess the adhesion force and neutrophil cell membrane stiffness (the Young's modulus). Results . Blood neutrophil and thrombocyte numbers, CRP and fibrinogen levels were significantly higher in patients with COPD + PH compared to COPD patients without PH. Relationships were found between systemic inflammation biomarkers and systolic pulmonary artery pressure. Conclusion . The results demonstrated that the membrane stiffness and the adhesion force were

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