Snoring and Cardiovascular Disease Risk in Midlife Women: A Mechanistic Model of Snoring-Related Atherogenesis and Associations with C-Reactive Protein

TL;DRAbstract

Simple snoring is highly prevalent and should be considered a phenomenon distinct from sleep disordered breathing (SDB). Snoring is associated with cardiovascular disease (CVD) morbidity and mortality. Midlife women are at increased risk for snoring and cardiovascular disease, yet little is known about the relationships between these factors in this population. We propose and test a mechanistic model of snoring-related atherogenesis to explain these associations. This is the first study to examine the relationship in midlife women between objective and subjective snoring and C-reactive protein (CRP), a CVD biomarker, and the first study to characterize the correlates of snoring in midlife women. The full multi-ethnic sample included 300 women (52.07 ± 2.13 years, 44% African American) from the SWAN Sleep Study, ancillary to the Study of Women’s Health Across the Nation (SWAN). Objective snoring and apnea-hypopnea index (AHI) were measured in a subset of 241 participants on one night of

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