Imagerie des couches corticales par résonance magnétique à 7 teslas

TL;DRAbstract

This thesis presents the development of a methodology for the analysis of the layered structure of the cerebral cortex, using high-field magnetic resonance imaging (7-tesla MRI). While cortical layers are traditionally studied using microscopic imaging of post-mortem tissue slices, the use a non-invasive technique such as MRI will enable in vivo studies, and thus allow new approaches beyond the use of classical architectural atlases such as Brodmann's.Two imaging methodologies have been used to acquire high-resolution images. First, a method based on super-resolution reconstruction from thick slices acquired in different geometries was developed for in vivo imaging. Second, a three-dimensional imaging sequence optimized for post-mortem tissue allowed imaging excised brain specimen.The main contribution of this thesis consists of a pair of methods that perform an automatic extraction of cortical profiles, which characterize the laminar architecture at any cortical location. In order to

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