Spatial Aspects of Catalysis by Mitochondrial Aspartate Aminotransferase

TL;DRAbstract

Inspection of the structural models of five refined crystal structures of different unliganded and liganded forms of mitochondrial aspartate aminotransferase (McPhalen et al.P this Volume) has led to a number of observations about ligand binding and conformational changes involving both the “small domain” and the coenzyme that are relevant to the catalytic mechanism of this enzyme.

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