Expression and regulation of water channels and ion transporters : Ontogenic aspects

TL;DRAbstract

<p>The content and distribution of body water changes dramatically during the perinatal period and in infancy. Transport of water across the cell membrane occurs via diffusion and via specific water channels. Transport via water channels is fast and may be hormonally regulated.</p><p>The main purpose of this thesis has been to study the peri- and postnatal development and regulation of water channels. Since water movement via water channels is dependent on ionic gradients, I also studied the postnatal expression of some ion transporters. Removal of rat lung liquid at birth was associated with pronounced changes in the expression of water channels, aquaporins (AQP) and ion transporters. The level mRNA levels of AQP1, Na+,K+-ATPase al, and amiloride sensitive sodium channel increased from embryonic day 18 (E18) to birth and continued to increase postnatally. There was a sharp and transient induction of AQP4 mRNA. The AQP4 protein was present in bronchial epithelial cell

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