Radioprotectant Effects of Cu(II)(3,5-DIPS)2

doi:https://doi.org/10.1007/978-1-4612-4584-1_33

Book Chapter10.1007/978-1-4612-4584-1_33

Radioprotectant Effects of Cu(II)(3,5-DIPS)2

Hamid Salari,Max L. Baker,John B. Barnett,Lee S.F. Soderberg,William M. Willingham,John R. J. Sorenson-1987-01-01-Humana Press eBooks

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TL;DRAbstract

Ionizing radiation of oxygenated aqueous solution is known to produce superoxide as a secondary product of radiation,1–3 Part of the cellular injuries caused by radiation can be attributed to the acute increase of superoxide. Addition of Cu-Zn superoxide dismutase (Cu-Zn SOD) to the extracellular medium can significantly protect cultured cells against radiation damage.4 Adding Cu-Zn SOD to cultures of myoblasts protected them from a radiation-induced decrease in viability and altered morphology5 as well as chromosomal damage.6

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Ionizing radiation of oxygenated aqueous solution is known to produce superoxide as a secondary product of radiation,1–3 Part of the cellular injuries caused by radiation can be attributed to the acute increase of superoxide. Addition of Cu-Zn superoxide dismutase (Cu-Zn SOD) to the extracellular medium can significantly protect cultured cells against radiation damage.4 Adding Cu-Zn SOD to cultures of myoblasts protected them from a radiation-induced decrease in viability and altered morphology5 as well as chromosomal damage.6

Keywords

Superoxide dismutaseSuperoxideIonizing radiationChemistryRadiation damageExtracellularReactive oxygen speciesRadiation

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