Abstract 17634: Increase in Epicardial Fat Volume is Associated with Greater Coronary Artery Calcification Progression in Subjects at Intermediate Risk by Coronary Calcium Score: A Serial Study Using Non-Contrast Cardiac CT

TL;DRAbstract

Objective: Epicardial fat volume (EFV) is related to calcified coronary plaques. However, it is unknown whether baseline EFV or changes in EFV affect the progression of coronary artery calcification over time. Methods: We identified 375 consecutive asymptomatic subjects with an intermediate risk of developing coronary heart disease [1) a man ≥55 years or woman ≥65 years or 2) a man 45-54 years or woman 55-64 years with at least 1 traditional CAD risk factor and baseline coronary calcium score (CCS) 50-399] who underwent serial non-contrast CT at least 3-5 years apart. Subjects were divided into tertiles of CCS progression (% increase) between the 2 scans. Subjects from the upper tertile (High Progressors) were matched by age and gender to 81 subjects from the lower tertile (Low Progressors). All subjects underwent serial measurements of CCS and EFV. The relationship between EFV and CCS progression, and changes in plaque number were compared between the two groups. Results: At baseline,

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