Abstract 273: A Blinded Evaluation of Combination Drug Therapy for Prolonged Ventricular Fibrillation Cardiac Arrest
TL;DRAbstract
Background : There are many examples of medical disease treatment innovating from single agent, failure-based, serial medication delivery to first-line combination drug therapy. Could the same approach improve outcomes in the metabolic phase of VF? Objective: Using a swine model of prolonged VF, we compared ROSC and 20-minute survival in animals treated with single agents given in series to animals provided first-line combination drug therapy. Methods : The study was IACUC approved. Eighty swine (25-30 kg) were surgically instrumented under anesthesia, and VF was electrically induced. After 12 minutes of untreated VF, animals were 2:1 block randomized to 1 of 2 resuscitation schemes. SERIES (n=53) received: epinephrine (0.01 mg/kg [SDE]); vasopressin (0.57 mg/kg); amiodarone (4.3 mg/kg) and SDE; sodium bicarbonate (1 mEq/kg) and SDE - each delivery punctuated by a RS after 3 minutes of CPR. If ROSC occurred after any RS, supportive care was provided and subsequent medications were not
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Background : There are many examples of medical disease treatment innovating from single agent, failure-based, serial medication delivery to first-line combination drug therapy. Could the same approach improve outcomes in the metabolic phase of VF? Objective: Using a swine model of prolonged VF, we compared ROSC and 20-minute survival in animals treated with single agents given in series to animals provided first-line combination drug therapy. Methods : The study was IACUC approved. Eighty swine (25-30 kg) were surgically instrumented under anesthesia, and VF was electrically induced. After 12 minutes of untreated VF, animals were 2:1 block randomized to 1 of 2 resuscitation schemes. SERIES (n=53) received: epinephrine (0.01 mg/kg [SDE]); vasopressin (0.57 mg/kg); amiodarone (4.3 mg/kg) and SDE; sodium bicarbonate (1 mEq/kg) and SDE - each delivery punctuated by a RS after 3 minutes of CPR. If ROSC occurred after any RS, supportive care was provided and subsequent medications were not
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