Lacrimal osmolaritu and ocular surface in experimental model of dry eye caused by toxicity

doi:https://doi.org/10.5935/0034-7280.20150016

Open AccessArticle10.5935/0034-7280.20150016

Lacrimal osmolaritu and ocular surface in experimental model of dry eye caused by toxicity

Davi Marques,Mônica Alves,Carolina Maria Módulo,Lilian Eslaine Costa Mendes da Silva,Peter S. Reinach,Eduardo Melani Rocha-2015-01-01-Revista Brasileira de Oftalmologia

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TL;DRAbstract

Purpose: Describe an animal model of dry induced by topical instillation of BAK and evaluate ocular surface biomarkers and histological findings. Methods: Male Wistar rats were used.Topical instillation of 0.2% BAK eyedrops twice a day during 7 days, in the right eye of each animal, while the other eye was taken as control. After 7 days treatment, we performed evaluation of tear film osmolarity, the red phenol thread and ocular surface staining with fluorescein and lissamine green. Afterwards, the animals [...]

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Purpose: Describe an animal model of dry induced by topical instillation of BAK and evaluate ocular surface biomarkers and histological findings. Methods: Male Wistar rats were used.Topical instillation of 0.2% BAK eyedrops twice a day during 7 days, in the right eye of each animal, while the other eye was taken as control. After 7 days treatment, we performed evaluation of tear film osmolarity, the red phenol thread and ocular surface staining with fluorescein and lissamine green. Afterwards, the animals [...]

Keywords

OphthalmologyLacrimal glandFluoresceinAnimal modelMedicineConjunctivaDry eyesPathology

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