The effect of generational feeding of soy and genistein-supplemented diets on progression of precancerous lesions in colon of second generation male rats

TL;DRAbstract

Colon cancer is the third leading cause of cancer related death in the United States. Epidemiological evidence has shown that populations who consume a traditional East Asian diet high in soy isoflavones have a reduced incidence of developing colon cancer. In previous studies, soy and isoflavones have also been shown to have an effect on reducing colon cancer growth and progression in vitro and in vivo. This study used Sprague Dawley male rats from the second generation of a multiple generation model, which were fed a control, soy, or genistein-supplemented diet. Soy and genistein fed rats had dietary exposure from two previous generations, consumed the same diet and therefore were exposed through gestation, lactation, and post-weaning. Control group rats were obtained at six weeks of age. At ten weeks of age, the rats were injected with azoxymethane (AOM) and were sacrificed at fifteen weeks. Descending colon tissue was collected for physiological, protein, and genetic analysis. Ident

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