EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration. European Respiratory

TL;DRAbstract

The European Early Lung Cancer (EUELC) project aims to determine if specific
\ngenetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium.
\nIn order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk
\nof developing progressive lung cancer were recruited from 12 centres in eight European
\ncountries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In
\naddition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial
\nTissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of
\nbiological specimens.
\nThe molecular–pathological investigations were subdivided into specific work packages that
\nwere delivered by EUELC Partners. The work packages encompassed mutational analysis,
\ngenetic instability, methylation profiling, expression profiling utilising immunohistochemistr

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