How Modification of Dietary FODMAP Intake Impacts Blood Glucose and Fasting Breath Hydrogen

TL;DRAbstract

Diets low in fermentable oligo-,di, mono-saccharides and polyols (FODMAPs) have gained notoriety due to their ability to mitigate symptomology associated with irritable bowel syndrome. However, increased consumption of dietary FODMAPs could exert a prebiotic effect resulting in reduced post-prandial blood glucose. The purpose of this study was to examine how changes in FODMAP consumption effect blood glucose. Fasting breath hydrogen (BH2) was examined as an indicator of colonic fermentation. This study utilized a single blind, randomized, crossover design. Healthy participants (n=16, 20.5±1.7yrs, BMI 22.2±2.4kg/m2) were instructed to follow a low FODMAP (LFD) and high FODMAP (HFD) diet for three days each separated by an 11-day washout. Blood glucose was measured in fasting and post-prandial state. Data were analyzed via ANOVA. Total area under the curve (TAUC) was calculated for blood glucose. Blood glucose TAUC was reduced with HFD, but not significantly (6722±861 vs. 7149±1120 mg/dl

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