RADIOACTIVE ANTI-TUMOR ANTIBODIES

TL;DRAbstract

When antibodies prepared against tumors are labelled with radioactive isotopes, it is possible to determine whether such abtibodies localize specifically in the tumor. There is. moreover, the possibility that radiolabelled antibodies can be used diagnostically to determine the location of tumors and their metastases and perhaps therapeutically to carry physiological amounts of radioactivity to the tumor. Preparations from antitumor serums localized in the tumor only slightly more than did control serum ppreparations. Tumor localizing antibodies were contaminated with antiobodies capable of localizing elsewhere in normal tissues. Methods have now been developed which permit specific purification of radiodinated anti-tumor antibodies so that as much as 36% of the injected material has been observed to localize in the Murphy lymphosarcoma of rats (the tumor most intensively studies) and cross-localizing activity has been largely minimized. These two improvements were accomplished by speci

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