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J M Bland-1994-01-29-BMJ
2

TL;DRAbstract

antibodies, particularly their opsonising activity.Assays are available in our unit to measure the ability of patients' serum to opsonise pneumococci and enhance the ingestion of these organisms by phagocytes.These tests may supplement quanti- tative antibody tests in determining the need for reimmunisation.As pneumococcal vaccine contains capsular polysaccharide from only 23 serotypes of Streptococcus pneumoniae it does not provide full protection against pneumococcal septicaemia, and lifelong prophylaxis with antibiotics must be recommended.The reported incidence of pneu- mococcus that is resistant to penicillin, however, is over 40% in Spain,' which makes it crucial to recommend antibiotics resistant to penicillinase for high risk patients.Finally, Capnocytophage canimorsus must be added to the list of organisms of which people who have undergone splenectomy and have contact with animals should be aware.This organism can be transmitted by animal bites, especially dog bites, and can

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antibodies, particularly their opsonising activity.Assays are available in our unit to measure the ability of patients' serum to opsonise pneumococci and enhance the ingestion of these organisms by phagocytes.These tests may supplement quanti- tative antibody tests in determining the need for reimmunisation.As pneumococcal vaccine contains capsular polysaccharide from only 23 serotypes of Streptococcus pneumoniae it does not provide full protection against pneumococcal septicaemia, and lifelong prophylaxis with antibiotics must be recommended.The reported incidence of pneu- mococcus that is resistant to penicillin, however, is over 40% in Spain,' which makes it crucial to recommend antibiotics resistant to penicillinase for high risk patients.Finally, Capnocytophage canimorsus must be added to the list of organisms of which people who have undergone splenectomy and have contact with animals should be aware.This organism can be transmitted by animal bites, especially dog bites, and can

Keywords

Confidence intervalNull hypothesisStatisticsPopulationTest (biology)Significant differenceStatistical hypothesis testingDemography

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