Protecting third parties in human subjects research.

TL;DRAbstract

consider the following hypothetical study submitted to an Institutional Review Board (IRB). An investigator proposes to compare the effectiveness of two commercially available kits that test for the presence of cockroach allergens in the home. Exposure to cockroach allergens can exacerbate asthma and cause other respiratory problems.' The study will recruit 50 heads of households through newspaper and radio advertisements to participate in the study. Volunteers will be asked to use each of the two test kits according to instructions and to complete a questionnaire on their experience afterward. As part of the study, a professional exterminator will examine each home following the use of the test kits to ascertain whether cockroaches are present. If appropriate, the exterminator will apply a commercially available pesticide in areas of the home to exterminate cockroaches and place pesticide traps in strategic spots to reduce the likelihood of future cockroach presence. Two months after

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