Assessment of a novel biomarker panel for the earlier prediction of acute kidney injury in patients with diabetes mellitus undergoing coronary angiography and intervention

TL;DRAbstract

Diabetes mellitus triples the risk of developing coronary heart disease (CHD). The manifestations of CHD are more severe in patients with diabetes with both more extensive and more diffuse disease. Outcomes in patients with diabetes are significantly worse both in terms of Major Adverse Cardiovascular Events (MACE) overall and specifically following revascularisation procedures such as percutaneous coronary intervention (PCI). Furthermore patients with chronic kidney disease (CKD) are excluded from the vast majority of cardiology trials and therefore there is a lack of data for these patients. Contrast induced acute kidney injury (AKI) is an important complication following procedures in the cardiac catheterisation laboratory and patients with diabetes are at particular risk. Patients with diabetes and CKD are a particular challenge. They have an extremely high incidence of co-morbidities such as CHD and peripheral vascular disease (PVD). When renal function is already impaired by othe

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