Oncogenes as Regulators of Cell Survival

doi:https://doi.org/10.1007/978-1-59259-313-2_9

Open AccessBook Chapter10.1007/978-1-59259-313-2_9

Oncogenes as Regulators of Cell Survival

Kirill V. Rosen,Jorge Filmus-2003-01-01-Humana Press eBooks

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TL;DRAbstract

During the past few years, it has become obvious that resistance to programmed cell death, or apoptosis, plays a major role in the process of malignant transformation and subsequent tumor progression. Molecular mechanisms of such resistance induced by the activation of various proto-oncogenes and the loss of activity of tumor suppressor genes have begun to emerge. In parallel, our knowledge of the principles governing the functioning of the intrinsic cell death machinery has expanded considerably.

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During the past few years, it has become obvious that resistance to programmed cell death, or apoptosis, plays a major role in the process of malignant transformation and subsequent tumor progression. Molecular mechanisms of such resistance induced by the activation of various proto-oncogenes and the loss of activity of tumor suppressor genes have begun to emerge. In parallel, our knowledge of the principles governing the functioning of the intrinsic cell death machinery has expanded considerably.

Keywords

SuppressorApoptosisProgrammed cell deathBiologyCell biologyCancer researchGeneCell

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