Preliminary toxicological study of Silastic 386 foam elastomer: catalyst
TL;DRAbstract
The acute oral LD/sup 30//sub 50/ values in mice and rats for cured Silastic 386 (95 parts foam elastomer plus 5 parts catalyst) were greater than 5 g/kg. According to classical guidelines, the mixture would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the mixture to be mildly irritating. Eye irritation studies, also in the rabbit, showed the cured Silastic 386 to be a mild but transitory irritant. The sensitization study in the guinea pig did not demonstrate the mixture to be a sensitizer.
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The acute oral LD/sup 30//sub 50/ values in mice and rats for cured Silastic 386 (95 parts foam elastomer plus 5 parts catalyst) were greater than 5 g/kg. According to classical guidelines, the mixture would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the mixture to be mildly irritating. Eye irritation studies, also in the rabbit, showed the cured Silastic 386 to be a mild but transitory irritant. The sensitization study in the guinea pig did not demonstrate the mixture to be a sensitizer.
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