大肠癌E-cadherin, β-catenin, MMP-7表达及其临床意义

TL;DRAbstract

AIM: To detect expression of E-cadherin, 13-catenin and matrix metalloproteinase-7 (MMP-7) as well as their correlations in colorectal carcinoma (CRC). METHODS: Immunohistochemistry was used to detect the expression of E-cadherin, β-catenin and MMP-7 protein in 60 specimens of CRC and 8 specimens of normal colorectal tissues. The corresponding clinical data were analyzed retrospectively. RESULTS: The positive rates of E-cadherin, normal β-catenin, abnormal β-catenin and MMP-7 expression in CRC were 73.3%, 66.7%, 63.3% and 73.3%, respectively, which were significantly correlated with the depth of invasion and lymph node metastasis, but not with the age, sex and tumor size or position and differentiation of the patients'. The normal expression of β-catenin was positively correlated with E-cadherin expression (r=0.359, P=0.005) in CRC, but negatively correlated with the abnormal expression of β-catenin (r=-0.324, P=0.012). There existed positive correlation between the expression of MMP-7

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