Dielectrophoresis based methods for separating particles on lab-on-chip platforms

TL;DRAbstract

Lab-on-chip devices are an emerging microsystem technology in which laboratory functions are miniaturized into compact, chip-scale packages. Such devices enable analyses to be performed at lower cost and higher speed than with traditional methods. One major application area for these devices is their use in sorting and separating biological particles. In this dissertation, we present a new technique for separating biological particles on lab-on-chip platforms. The foundation of our method is dielectrophoresis, a technique where AC electric fields are used to manipulate particles in a fluid, based on their inherent electrical properties. These electrical properties reflect differences not just in size, but also capture subtle variations in the internal composition of the particle. Using a novel time-multiplexed combination of dielectrophoresis methods over very dense electrode arrays, we can create strong electric fields with a high degree of spatial resolution. When placed in the prese

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