Association Studies in Asthma

TL;DRAbstract

Association studies may be defined as population-based genetic studies thatexamine whether a particular allele or a series of alleles in one or moregenes occur at a significantly higher rate with a disease phenotype thanwould otherwise be expected. This method yields statistical estimates of whether a polymorphism is a marker, or contributor, to disease susceptibil-ity. A positive association may occur because: (i) the polymorphism is atrue causal variant, (ii) of a type I error (an association was detected thatoccurred by chance), (iii) of inherent study biases, or (iv) of linkage witha causal variant. The inability to detect an association may be because of:(i) the polymorphism is not causal, (ii) type II error (not detecting an asso-ciation when one exists) usually because of a lack of statistical power, or(iii) lack or weakness of a necessary environmental stimulus (1). Despite the high potential for erroneously identifying a polymorphism as a causalvariant, association studies to

Chat with Paper

AI Agents for this Paper