Defective CD8+ T cell effector function in pathogenic influenza infection (49.7)

TL;DRAbstract

Abstract Many questions about CD8+ T cell responses during influenza infection remain unanswered. We therefore examined the development and differentiation of CD8+ T cell memory populations based on specificity and effector function in a mouse model system comparing high and low pathological infections of influenza. Our findings reveal that initial or peak viral titer was not the determining factor in the outcome of disease. Instead, differences in CD8+ T cell effector function were observed for each virus type (high and low pathogenic), and these differences correlated with disease outcome. Further investigation has demonstrated that differences in the airway microenvironment after infection with high and low path infections may significantly affect CD8+ T cell activity. Specifically, increased early production of certain cytokines is associated with highly pathogenic infection. We hypothesize that this altered airway microenvironment results in downmodulation of CTL function via esta

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